Shire Pharmaceuticals Inc. 401(k) Savings Plan Investment Model Portfolios

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Investment options of Shire Pharmaceuticals Inc. 401(k) Savings Plan

Total Available Funds: 27

Asset Class

Ticker

Description

Others
ROOT	CASH	Fidelity Investments Interest Bearing Cash
Target Date 2000-2010	FFFBX	Fidelity Investments Fidelity Freedom 2000
Target Date 2000-2010	FFFVX	Fidelity Investments Fidelity Freedom 2005
Target Date 2000-2010	FFFCX	Fidelity Investments Fidelity Freedom 2010
Target Date 2011-2015	FFVFX	Fidelity Investments Fidelity Freedom 2015
Target Date 2016-2020	FFFDX	Fidelity Investments Fidelity Freedom 2020
Target Date 2021-2025	FFTWX	Fidelity Investments Fidelity Freedom 2025
Target Date 2026-2030	FFFEX	Fidelity Investments Fidelity Freedom 2030
Target Date 2031-2035	FFTHX	Fidelity Investments Fidelity Freedom 2035
Target Date 2036-2040	FFFFX	Fidelity Investments Fidelity Freedom 2040
Target Date 2041-2045	FFFGX	Fidelity Investments Fidelity Freedom 2045
Target Date 2050+	FFFHX	Fidelity Investments Fidelity Freedom 2050
Retirement Income	FFFAX	Fidelity Investments Fidelity Freedom Income
unknown	unknown	Fidelity Investments Managed Income Fund Portfolio

FIXED INCOME
Intermediate-Term Bond	PTTRX	Pacific Investment Management Company Funds Pacific Investment Management Company Total Return Institutional
Multisector Bond	NEFZX	Natixis Funds Loomis Sayles Strategic Income A

US EQUITY
LARGE VALUE	PNEAX	Allianz Funds Allianz NFJ Dividend Value Institutional
LARGE BLEND	SRVEX	Victory Funds Victory Diversified Stock A
LARGE GROWTH	RGAFX	American Funds American Funds Growth Fund of Amer R5
Mid-Cap Growth	MPEGX	Morgan Stanley Funds Morgan Stanley Inst Mid Cap Growth I
SMALL BLEND	KSCVX	Keeley Funds Keeley Small Cap Value A
Small Growth	PSGIX	BlackRock Funds BlackRock Small Cap Growth Equity Institutional
MID-CAP BLEND	FSEMX	Fidelity Investments Fidelity Spartan Extended Mkt Index Inv
LARGE BLEND	FUSVX	Fidelity Investments Fidelity Spartan US Equity Index Fund
MID-CAP VALUE	FDVLX	Fidelity Investments Fidelity Value

INTERNATIONAL EQUITY
Foreign Large Blend	RERFX	American Funds American Funds EuroPacific Growth R5

Emerging Market
DIVERSIFIED EMERGING MKTS	ODMAX	Oppenheimer Funds Oppenheimer Developing Mkts A

Investment model portfolios

We provide two types of investment model portfolios for Shire Pharmaceuticals Inc. 401(k) Savings Plan participants. You can customize and follow a model portfolio in your plan account.

Types of portfolio strategies

Strategic asset allocation portfolio: It invests in a diversified portfolio of multiple assets, buy-and-hold without frequently changing the asset allocation weights.
- Suitable: For long-term (more than 15 years, preferably more than 20 years), want to be tax efficient and can withstand interim drawdown or loss as high as 50% or more.
- Pros:
  - Less error-prone
  - Infrequent rebalancing or transactions
  - Tax efficient for taxable brokerage investments
- Cons:
  - Interim loss or drawdown can be substantial
  - Possible low returns for an extended period, such as 10 years or longer
Tactical asset allocation portfolio: it invests in a diversified portfolio of multiple assets, dynamically adjust stock and bond allocations to minimize losses during market stress.
- Suitable: For long-term (more than 10 years or preferably longer) capital. Investors are willing to rebalance as frequent as monthly.
- Pros:
  - Reduce large interim loss or drawdown
  - Less sensitive to investment entry point
  - Likely to improve returns
- Cons
  - Demand more frequent rebalancing or transactions
  - Less tax efficient — more suitable in a tax-deferred account such as 401(k) or IRA
  - Can experience a period of lower returns compared to a broad-based strategic allocation or a buy-and-hold benchmark, especially in some bull markets

These portfolios are proactively monitored and rebalanced on a monthly basis when needed, ensuring it remains in line with its target allocation.

Let us know (Email us) if you need help to create a custom model portfolio for your plan.

Customize a model portfolio now

Example model portfolios

The following provides historical returns for example model portfolios with a moderate risk profile (at most 60% in stocks) and their comparison with benchmark index funds. You can customize these portfolios according to your own risk profile.

Strategic Asset Allocation Model Portfolio

The following portfolio is based on the MyPlanIQ Strategic Asset Allocation (SAA) strategy.

Tactical Asset Allocation Model Portfolio

The following portfolio is based on the MyPlanIQ Tactical Asset Allocation (TAA) strategy.

Name	YTD Return	1Yr AR	3Yr AR	5Yr AR	10Yr AR	15Yr AR	20Yr AR	Common	Inception
Shire Pharmaceuticals Inc. 401(k) Savings Plan Tactical Asset Allocation Moderate	NA	2.11%	1.72%	0.82%	1.79%	4.38%	6.61%	…	…
VFINX (VANGUARD 500 INDEX FUND INVESTOR SHARES)	NA	9.98%	9.75%	10.95%	11.06%	12.38%	9.19%	…	…
VSMGX (VANGUARD LIFESTRATEGY MODERATE GROWTH FUND INVESTOR SHARES)	NA	6.25%	1.69%	4.40%	4.69%	6.67%	5.54%	…	…

	Ticker/Portfolio	Last 1 Week	1 Yr	3 Yr	5 Yr	10 Yr	15 Yr	20 Yr	Common	Inception	YTD	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014	2013	2012	2011	2010	2009	2008	2007	2006	2005	2004	2003	2002	2001	2000	1999	1998	1997	1996	1995	1994	1993	1992	1991	1990	1989	1988	1987	1986	1985	1984	1983	1982	1981	1980	1979
Annualized Return (%)	Shire Pharmac… Moderate	-0.48	2.11	1.72	0.82	1.79	4.38	6.61	…	…	NA	NA	0.39	15.19	-16.35	7.73	9.07	4.34	-4.91	12.73	4.60	-2.20	0.93	12.63	5.58	-5.72	10.40	28.38	-8.15	22.27	17.82	17.36	14.32	33.92	9.62	4.98	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	VFINX (VANGUA…R SHARES)	-1.25	9.98	9.75	10.95	11.06	12.38	9.19	…	…	NA	17.72	24.84	26.12	-18.24	28.53	18.74	31.33	-4.55	21.66	11.83	1.23	13.52	32.17	15.82	1.96	14.91	26.52	-37.02	5.39	15.64	4.77	10.74	28.50	-22.17	-12.03	-9.05	21.08	28.62	33.18	22.87	37.45	1.18	10.15	8.24	32.05	-3.33	28.37	14.92	3.97	9.30	22.60	3.67	17.07	19.25	-8.55	27.89	-2.07
	VSMGX (VANGUA…R SHARES)	-0.67	6.25	1.69	4.40	4.69	6.67	5.54	…	…	NA	16.26	10.28	15.51	-16.01	10.08	13.59	19.30	-6.28	14.86	7.09	-2.21	6.38	14.73	9.78	0.12	13.14	20.35	-26.49	7.21	13.30	5.68	11.76	22.40	-10.34	-4.78	1.27	14.09	21.59	17.90	10.77	26.58	2.04	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Sharpe Ratio	Shire Pharmac… Moderate	NA	0.43	-0.08	0.18	0.24	NA	NA	…	…	NA	NA	0.01	1.24	-1.64	0.73	0.95	0.57	-0.87	1.86	0.77	-0.43	0.15	1.89	0.96	-0.56	0.92	2.86	-1.35	1.43	1.42	2.33	1.54	5.86	1.77	0.65	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	VFINX (VANGUA…R SHARES)	NA	1.89	1.22	0.63	0.75	NA	NA	…	…	1.30	0.80	1.67	1.73	-0.82	2.17	0.53	2.39	-0.35	3.16	0.89	0.08	1.19	2.90	1.25	0.08	0.82	0.97	-0.92	0.14	1.22	0.24	0.88	1.63	-0.90	-0.68	-0.60	0.97	1.23	1.61	1.62	4.31	-0.19	0.90	0.57	1.91	-0.55	1.71	0.59	-0.01	0.30	1.47	-0.26	0.79	0.63	-1.30	1.17	-3.84
	VSMGX (VANGUA…R SHARES)	NA	1.70	1.15	0.38	0.62	NA	NA	…	…	1.08	1.36	0.87	1.45	-1.22	1.32	0.70	2.77	-0.87	3.75	0.83	-0.26	1.01	2.16	1.23	0.01	1.18	1.12	-0.98	0.39	1.34	0.49	1.49	2.09	-0.75	-0.59	-0.24	1.06	1.56	1.56	0.91	4.18	4.60	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Standard Deviation(%)	Shire Pharmac… Moderate	NA	8.70	10.02	9.20	7.82	NA	NA	…	…	NA	NA	8.16	8.82	10.80	10.60	9.28	5.13	7.11	6.50	5.69	5.20	6.26	6.65	5.73	10.26	11.25	9.89	6.71	13.48	10.27	6.51	8.69	5.67	4.82	4.14	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	VFINX (VANGUA…R SHARES)	NA	12.22	14.87	16.92	18.13	NA	NA	…	…	13.93	18.66	12.67	13.09	24.19	13.11	34.69	12.48	17.11	6.68	13.11	15.51	11.39	11.07	12.74	23.36	18.07	27.22	40.99	16.02	10.04	10.29	11.10	17.04	25.96	21.55	22.20	18.17	20.48	18.21	11.77	7.77	9.92	8.83	9.93	14.69	16.06	13.09	17.07	33.80	16.55	11.67	12.80	13.62	18.09	14.61	16.53	23.80
	VSMGX (VANGUA…R SHARES)	NA	8.47	8.97	10.05	10.33	NA	NA	…	…	10.48	9.89	7.69	8.26	14.34	7.62	19.08	6.43	8.81	3.80	8.31	8.51	6.28	6.80	7.99	14.68	11.10	18.01	27.95	10.37	7.43	6.96	7.25	10.38	15.37	12.42	12.30	10.07	11.65	9.10	7.74	5.41	15.57	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Draw Down(%)	Shire Pharmac… Moderate	NA	8.11	18.23	18.23	18.23	NA	NA	…	…	NA	NA	2.30	8.11	16.57	4.96	13.63	3.61	10.76	5.44	3.74	6.74	5.76	5.07	6.75	11.85	9.30	4.77	12.09	11.09	15.20	5.24	9.96	3.26	5.38	3.54	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	VFINX (VANGUA…R SHARES)	NA	8.92	18.76	24.59	33.83	NA	NA	…	…	8.92	18.76	8.45	9.97	24.59	5.14	33.83	6.63	19.40	2.60	10.29	12.05	7.30	5.59	9.60	18.71	15.66	27.17	47.73	9.88	7.47	7.01	7.47	13.79	33.02	29.18	16.55	11.81	19.20	10.79	7.45	2.50	8.48	4.84	5.63	5.57	19.19	7.35	7.24	33.08	11.63	7.51	10.58	7.02	13.21	15.61	16.03	2.40
	VSMGX (VANGUA…R SHARES)	NA	6.64	9.62	22.29	22.43	NA	NA	…	…	6.64	9.62	4.17	8.15	21.74	3.53	22.43	3.12	11.47	1.14	6.20	8.34	4.70	5.67	6.27	12.90	8.64	19.61	36.81	6.11	6.13	4.74	5.89	8.91	20.06	17.93	8.77	6.26	11.99	6.02	4.75	1.82	1.89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Yield(%)	Shire Pharmac… Moderate	NA	5.14	4.67	4.12	3.69	NA	NA	…	…	NA	NA	0.16	5.45	1.71	7.18	3.26	3.29	3.48	0.40	2.75	5.14	4.65	0.51	3.58	2.05	2.24	4.37	2.66	9.38	8.00	4.73	3.15	5.96	6.41	7.28	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	VFINX (VANGUA…R SHARES)	0.00	1.17	1.59	1.52	2.77	3.90	3.50	…	…	0.27	1.20	1.41	1.69	1.26	1.48	2.12	2.28	1.81	2.00	2.14	1.97	1.96	2.19	2.30	1.92	1.88	2.45	1.88	1.91	1.83	1.79	1.91	1.71	1.28	1.08	0.97	2.11	1.93	2.77	2.64	3.14	3.13	3.83	3.10	5.86	3.71	4.46	4.31	2.79	3.90	4.71	4.49	5.04	5.34	4.64	5.79	0.00
	VSMGX (VANGUA…R SHARES)	0.00	5.49	5.98	4.34	4.53	4.38	4.23	…	…	0.00	5.80	7.43	4.45	2.18	4.11	3.77	2.85	2.41	2.40	2.34	2.10	2.20	2.14	2.47	2.22	2.38	2.79	2.66	3.04	2.89	2.53	3.74	2.48	2.67	2.88	6.36	5.93	7.27	3.78	3.63	3.65	2.91	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA

Data as of 10/31/2023, Common starting date is 12/31/2000

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